Hypothyroidism Treatment Isn’t a One-Size-Fits-All Solution
Although T4 monotherapy is the standard treatment for hypothyroidism, there are some people who still experience persistent symptoms of hypothyroidism despite being on therapy.2 Some studies have shown that many patients find symptom relief with natural thyroid extracts (NTEs) and have better overall satisfaction with their treatment.2,3LEARN ABOUT HYPOTHYROIDISM T4, levothyroxine; T3, liothyronine
About ADTHYZA: A Natural Thyroid Extract
ADTHYZA tablets contain a combination of T4 and T3 thyroid hormones.4 Synthetic T4 monotherapies do not provide T3, but rely on the body to convert T4 to T3, which doesn’t happen naturally for everyone in the same way. Combination therapy, which includes both T4 and T3, was the first treatment for hypothyroidism.1
10% to 15% of people still have hypothyroidism symptoms
despite treatment with T4 alone.1Learn more about hypothyroidism
Manufactured and Tested to Ensure Quality and Consistency5,6
ADTHYZA undergoes strict batch-to-batch quality control to meet T4 and T3 potency standards before ever reaching you.5
Our manufacturing complies with all Current Good Manufacturing Practices (cGMP) and adheres to standards outlined by the US Pharmacopeia (USP).5 Each batch of ADTHYZA is 100% within range of USP standard.
Our manufacturing is backed by Azurity’s mission to make safe, high-quality treatments for patients.6
Confidence and Quality: Look Up Your Lot
We test every lot for quality, consistency, and potency.
Enter a package lot number below to see information.
Where’s the lot number?
Look at the bottom of the label on the package. You’ll see the word “LOT” followed by a number. Usually, it’s right above the expiration date. Enter that lot number in the box to search for test results.
Committed to Excellence
ADTHYZA is free of lactose, corn, dyes, and latex. For people with serious food allergies or restrictions, this can be an important consideration.4
- Contains T4
- Adheres to Independent USP Standards
- Contains T3
- Complies with CGMP Standards
ADTHYZA is an oral medication with flexible dosing for personalized medicine. It is available in 5 strengths to help your healthcare provider find the dose that works best
Once you begin taking ADTHYZA, it is important to continue taking it, and following your healthcare provider’s advice. They will monitor you and let you know if your dose needs to be adjusted. Keep in mind that it can take time for symptoms to improve.
Let your healthcare provider know if you start or stop any other medications.
Dosage Levels130 mg 97.5 mg 65 mg 32.5 mg
DOSE 16.25 mg
Guidelines for Taking ADTHYZA
8 oz of water
Take ADTHYZA at the same time every day with
8 ounces (oz) of water.7
Take ADTHYZA on an empty stomach, and then wait 30-60 minutes before eating or drinking anything other than water.7 If you’ve already eaten, wait 2 hours before taking ADTHYZA.
4 hours before or after taking ADTHYZA
Do you take iron supplements, calcium supplements, antacids, or cholestyramine? If so, take ADTHYZA at a different time—at least 4 hours before or after.8
Making Sure It's ADTHYZA at the Pharmacy
If your healthcare provider decides ADTHYZA is right for you, they may also need to include “Dispense as Written (DAW)” or “Brand Medically Necessary” with your prescription to prevent substitutions with a different hypothyroidism medication. If your pharmacy does not have ADTHYZA in stock, ask the pharmacist to order. Most pharmacy orders are delivered within one or two days.
Another great option is the ADTHYZA Cares Program, where starting on ADTHYZA is simple! Click below to learn how to get ADTHYZA shipped to you directly for a low cash price.
Please note that Adthyza® has not been reviewed by the FDA for safety or efficacy.
DRUGS WITH THYROID HORMONE ACTIVITY, ALONE OR TOGETHER WITH OTHER THERAPEUTIC AGENTS, HAVE BEEN USED FOR THE TREATMENT OF OBESITY. IN EUTHYROID PATIENTS, DOSES WITHIN THE RANGE OF DAILY HORMONAL REQUIREMENTS ARE INEFFECTIVE FOR WEIGHT REDUCTION. LARGER DOSES MAY PRODUCE SERIOUS OR EVEN LIFE-THREATENING MANIFESTATIONS OF TOXICITY, PARTICULARLY WHEN GIVEN IN ASSOCIATION WITH SYMPATHOMIMETIC AMINES SUCH AS THOSE USED FOR THEIR ANORECTIC EFFECTS.
ADTHYZA® (thyroid tablets, USP) is a prescription medicine indicated as replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis.
ADTHYZA® is also indicated as a pituitary TSH suppressant in the treatment or prevention of various types of euthyroid goiters, including thyroid nodules, subacute or chronic lymphocytic thyroiditis (Hashimoto’s), multinodular goiter, and in the management of thyroid cancer.
IMPORTANT SAFETY INFORMATION
Do not use ADTHYZA in patients with uncorrected adrenal cortical insufficiency, untreated thyrotoxicosis (high thyroid hormone levels), and apparent hypersensitivity to any component of the product.
The use of thyroid hormones for weight loss, alone or combined with other drugs, is unjustified and has been shown to be ineffective. Neither is their use justified for the treatment of male or female infertility unless this condition is accompanied by low thyroid levels.
Thyroid hormones should be used with great caution in circumstances where the integrity of the cardiovascular system is suspected. In the elderly and in patients with cardiovascular disease, ADTHYZA should be used with greater caution.
Tell your doctor about any other medical conditions you may have, especially heart disease, diabetes, blood clotting problems, and adrenal or pituitary gland problems. The dose of other drugs you may be taking to control these conditions may have to be changed while you are taking.
A reportedly apparent association between prolonged thyroid therapy and breast cancer has not been confirmed, and patients on thyroid for established indications should not discontinue therapy. No confirmatory long-term studies in animals have been performed to evaluate cancer causing potential, mutagenicity, or impairment of fertility in either males or females.
Thyroid replacement therapy for hypothyroid women should not be discontinued during pregnancy, and hypothyroidism diagnosed during pregnancy should be promptly treated. Minimal amounts of thyroid hormones are excreted in human milk. However, caution should be exercised when thyroid is administered to a nursing woman. Routine determinations of serum T4 and/or TSH are strongly advised in neonates in view of the deleterious effects of thyroid deficiency on growth and development.
Tell your doctor immediately if you experience chest pain, increased pulse rate, rapid, strong, irregular heartbeat, excessive sweating, or any other unusual event.
Partial loss of hair may be experienced by children in the first few months of thyroid therapy, but this is usually a transient phenomenon.
Many drugs and some laboratory tests may alter your therapeutic response to ADTHYZA.
Tell your doctor about all medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take medicines to treat and prevent blood clots (anticoagulants), antidiabetic agents, or oral contraceptives.
For further information, please see the accompanying complete Prescribing Information for ADTHYZA.
- 1. McAninch EA, Bianco AC. The swinging pendulum in treatment for hypothyroidism: from (and toward?) combination therapy. Front Endocrinol. 2019;10:446. doi:10.3389/fendo.2019.00446
- 2. Panicker V, Saravanan P, Vaidya B, et al. Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients. J Clin Endocrinol Metab. 2009;94(5):1623-1629. doi:10.1210/jc.2008-1301
- 3. Peterson SJ, Cappola AR, Castro MR, et al. An online survey of hypothyroid patients demonstrates prominent dissatisfaction. Thyroid Off J Am Thyroid Assoc. 2018;28(6):707-721. doi:10.1089/thy.2017.0681
- 4. Adthyza [prescribing information] Woburn, MA, Azurity Pharmaceuticals, Inc. 2023 https://adthyza.com/hcp/media/pdf/Adthyza_PI.pdf Prescribing Information
- 5. Data on file, 2022, Azurity Pharmaceuticals, Inc.
- 6. Azurity Compliance Program. Available online at https://azurity.com/compliance/ Azurity Compliance Program
- 7. Thyroid capsules or tablets. Cleveland Clinic. Accessed October 23, 2023. https://my.clevelandclinic.org/health/drugs/18645-thyroid-capsules-or-tablets Thyroid capsules or tablets
- 8. Jonklaas J, Bianco AC, Bauer AJ, et al. Guidelines for the treatment of hypothyroidism: prepared by the American Thyroid Association Task Force on thyroid hormone replacement. Thyroid. 2014;24(12):1670-1751 doi:10.1089/thy.2020.0720